Latest update

This release improves the lab core: faster native crafting and economy logic, stronger save encryption with automatic migration, and refreshed protection for shipped lab data and DLC packs (Palette Pack · Workbench Pack).

Real chemistry. Not fantasy alchemy.

Substance Lab Phouli is an educational chemistry game grounded in real scientific information—not magical potions or invented fantasy recipes. You combine substances based on real chemical reactions, study real materials, and learn through practice.

Crafting, quizzes, and rhythm modes share one goal: help you explore chemistry that actually exists in the real world.

Combine with real chemistry

Mix elements and compounds using combinations inspired by real reactions and formulas. Discover substances the way chemistry works—through structure, properties, and workable equations—not random fantasy crafting.

Build a growing library of real-world materials as you unlock new results through experimentation. Easy mode can hint at the reaction type; Hard mode asks you to name it first. Each attempt uses a combination stone.

Solve problems and quizzes

Test what you have learned with formula quizzes, element quizzes, and Find reaction. Problem-solving sits at the center of the experience, so progress comes from understanding—not only from collecting icons.

Rhythm challenges

Switch to rhythm minigames for short, focused sessions between study and crafting. Choose a track and difficulty. A different pace, same lab.

Periodic table and textbook

Browse all 118 elements, study groups and periods, and open a textbook of reaction types with examples from the lab.

Features

Combination gameplay based on real chemistry
Easy and Hard reaction modes
Formula quiz, element quiz, and Find reaction
Rhythm minigames with songs and difficulty
Full 118-element periodic table and textbook
Growing library of unlocked substances
Interface in 13 languages
Windows and macOS

Who is it for?

Players who want a chemistry learning game—not a fantasy alchemy RPG. If you like combining real substances, answering chemistry questions, and mixing in light rhythm play, this lab is for you.